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Department of

Medical Biotechnology and Translational Medicine

The Department of Medical Biotechnology and Translational Medicine, originated from matching interests and expertise in molecular and cellular sciences, sciences applied to medicine and clinical sciences, identifies research and teaching as two aspects to be integrated at most.

Cà Granda: facciata sul retro
Biometra Seminars

BioMeTra seminars 2018/2019

"New regenerative strategies for neural tissue repair” is the title of the next seminar of the cycle "BioMeTra seminars 2018/2019" that will take place on 10 July, at 2:00 pm at the Room E, LITA-Segrate.

Workshop Biometra

Biometra Workshop

The 3rd Biometra Workshop took place on September 24th 2018 at LITA Segrate.


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Focus on  

Extracellular vesicles, HERV-K and immune response

Extracellular vesicles (EVs) positive for human endogenous retroviruses (HERV) derived from two colorectal tumor cell lines: non-metastatic caco-2, and metastatic SK-CO-1, play a role in modulating the immune response innate in zebrafish.

NIPBL: a new player in myeloid cells differentiation

In adult patients with Acute Myeloid Leukemia and in zebrafish, the NPM1 mutation induces a reduction in NIPBL. We generated a the zebrafish model with down-regulation of NIPBL in which the myeloid precursors fail to differentiate. This phenotype is due to a hyper-activation of the canonical Wnt pathway.

Innate immunity controlling tumor metastasis: the MS4A4A molecule at the cross-road of macrophage / natural killer cell antitumoral networks

The results of an international study, directed by professsor Massimo Locati at his group at the Department of Medical Biotechnology and Translational Medicine, have just been published in Nature Immunology *. At the heart of the study, the discovery of the non-redundant role of the MS4A4A protein in activating a protective immune response against the metastatic spread of tumors. This molecule, which is selectively expressed in macrophages, a key cell type in innate immunity, was found to associate with the Dectin-1 receptor and control its function. By doing so, MS4A4A is essential to activate a dialogue between macrophages and Natural Killer cells which results in cancer cells killing and prevention of their metastatic spread.

BIOMETRA - edificio Farmacologia Medica  

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