2nd Call 2020 for post-doc fellowships (assegno di Ricerca tipo A)
Research line proposed by Biometra Department:
Chemistry and physics of biomolecules and cellular biophysics
Structure of peptides and proteins in aqueous media and in interaction with model membranes, by neutron and RX spectroscopy.
We propose to apply the techniques of diffusion, diffraction and reflection of radiation and neutrons to the study of the structure of proteins and peptides in aqueous media and in interaction with model membranes, mimes of cell membranes. The postdoc will join an ongoing experimental project. Feasibility studies and experiments have already been performed, justifying the application for beamtime at the European Large Scale Facilities, allowing for immediate operativity, within the rules and constraints of the present sanitary emergency.
Supervisors: prof Laura Cantù, prof. Elena Del Favero
Study of biomolecular systems with multivalent and cooperative interactions of proteins and nucleic acids for the development of rapid biosensors with enhanced sensitivity and specificity.
The need for rapid and sensitive methods to detect and quantify bio-markers and whole pathogens is ubiquitous in several diagnostic settings and the recent SARS-CoV-2 pandemic has made it even more evident. The project aims to study the effects of the multiplicity of interactions in protein / DNA systems of various types, both naturally occurring and synthetic, in order to design new bio-molecular probes with controlled cooperativity for next generation biosensors.
Supervisors: prof Marco Buscaglia, prof. Tommaso Bellini, prof. Giuliano Zanchetta
Conjugation with bioactive ligands to improve the anticancer activity of platinum derivatives
Side effects and resistance are major limitations to Platinum drugs tumor treatment. Binding them to other bioactive molecule could overcome these problems. Compounds with promising anticancer activity and improved pharmacological profiles have been reported. Thus planning hybrid compounds is considered a promising approach to obtain improvements of the actual Pt-based cancer therapy and also to get new molecular tools to deepen the knowledge of cancer and resistance mechanisms.
Supervisors: prof. Federica Compostella, prof. Diego Colombo