Mitochondria, metabolism, and longevity: new drugs and precision nutrition (Nisoli’s Lab)
Moreover, we found that these amino acid formulas can ameliorate mitochondrial dysfunction in diverse clinical settings: among others, drug-induced cardiotoxicity, alcohol-dependent liver damage, and genetic Duchenne muscular dystrophy. At present, we are characterizing a new nutritional strategy to healthy affect metabolic dysfunctions – altered glucose and lipid metabolism, defective energy homeostasis, and changed intestinal microbiota – typically observed in obese and diabetic patients, in addition to older adults. The strategy consists in substituting protein component of a diet with amino acid mixtures, specifically designed to improve energy metabolism in single tissue and organs. The overall aim is to identify selective nutrient combinations for single metabolic disorders.
Mitochondrial bioenergetics; nutrient metabolism; amino acid metabolism; nitric oxide; molecular mechanisms of aging; calorie restriction and intermittent fasting; mitochondrial pharmacology; anti-obesity, anti-diabetic, cardiovascular drugs
|Dario Brunetti, PhDfirstname.lastname@example.org|
|Maurizio Ragni, PhDemail@example.com|
|Chiara Ruocco, PhDfirstname.lastname@example.org|
|Laura Tedesco, PhDemail@example.com|
Office: +39 02 5031 6956
Laboratory: +39 02 50317116
Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, sede di via Vanvitelli 32, 20129 Milano; Stanza R016, Edificio 32110, Piano Rialzato.