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Genomic technologies  

Laboratory of genomic technologies

For several years our laboratory has been devoted to apply genomic technologies to study human diseases and cellular models using multidisciplinary approaches such as biochemistry, biology, biotechnology and bioinformatics. In particular, we have gained a lot of experience in the study of gene expression profiles in various biological samples (cell lines and clinical tissues) using microarray technology (home-made microarray and Affymetrix platform). In parallel, the group has been involved in the studying the genome variation (analysis of single nucleotide polymorphisms SNPs and copy number analysis) present in DNA samples obtained from human pathological specimens. Thanks to the presence of a multidisciplinary team and our strong relationships with groups of bioinformatics, we have developed bioinformatics methodologies to analyze and to integrate complex biological data.


Main research lines

Study of human tumors (renal cell carcinoma, melanoma) and models of cell lines (ATCC lines and primary cells) using genome-wide technologies to analyze genes and microRNA (gene expression profiling, microarrays): oncogenomics field
Study of rare diseases using genomics technologies such as microarray (SNP array) and deep sequencing (next generation sequencing): genomics field
Biological effects and human health impacts of ultrafine particles source
Assessments of methodologies for the integration of genomic data
Development of analytical methods applied to nucleic acids (DNA, RNA and microRNA) based on high-throughput platforms (Collaboration with ITB-CNR).


Grants (2016-2018)

Progetto CARIPLO: Biological effects and human health impacts of ultrafine particles source
Leader: Università Milano Bicocca; Partner Unit: ENEA e Università degli studi di Milano ; Time: two years project (from 1/04/2014 to 31/03/2016)
Progetto Piano di sostegno anno 2016 ( from University of Milan, BIOMETRA) : STUDY OF THE ROLE OF S561F CDKAL1 VARIANT IN INSULING PROCESSING AND SIGNALLING IN RAT PANCREATIC BETA CELLS (INS1-E), one year project

 

Group composition

The Research Group is composed by Dr. Cristina Battaglia (Associate Professor of Biochemistry, group leader) two PhD students (Andrea Grilli, Alex Pezzotta). Collaboration with Genomic Unit of ITB-CNR, Segrate: Gianluca De Bellis, Ingrid Cifola, Eleonora Mangano, Roberta Bordoni (http://www.itb.cnr.it/web/genomics/research). Others collaborations: Silvio Bicciato, Center for Genome Research Dept. of Life Sciences University of Modena and Reggio Emilia.

 

Contacts


Dott.ssa Cristina Battaglia  (E-mail. cristina.battaglia@unimi.it
Skype: cristina.battaglia
Phone : +390250330421
Location : L.I.T.A palace, via F. Cervi 93, 20090 Segrate (MI), Italy, 4th floor.
Orcid ID: http://orcid.org/0000-0003-3025-9657

 

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