Smac127 Has Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast
Smac 127 inhibits the IAP proteins in RA-FLSs cultured in tissue medium or in synovial fluid. RA-FLSs were grown in tissue medium (TM) or in synovial fluid (SF). Smac127 (15 𝜇M) was added for 48 hrs. (a) Immunoblots show the detection of cIAP1 (72 kDa), cIAP2 (70 kDa), and XIAP (55 kDa). 𝛽-actin was used as a loading control (42 kDa). (b) Densitometric analyses of the immunoblots show the ratio of IAPs/actin protein expression +/- SD of the mean from four independent experiments. #𝑝 < 0.05 indicates statistically significant differencesm compared to untreated RA-FLSs.
Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Mediators Inflamm. 2016;2016:6905678. doi: 10.1155/2016/6905678. Epub 2016 Feb 17.